Following the compound mediators on the severe result settle down, late-phase replies can often arise. This kind of is because of your migration of other leukocytes for example neutrophils, lymphocytes, eosinophils along with macrophages towards original internet site. The particular response is often seen 2–24 hrs after the first response.  Cytokines via mast cells may well be the cause inside the perseverance of long-term consequences. Late-phase replies noticed in asthma are a little bit not the same as those people noticed in other sensitized replies, even though they're nonetheless attributable to release of mediators via eosinophils and they are nonetheless relying on pastime of TH2 cells. [.